Sodium butyrate ameliorates erectile dysfunction through fibrosis in a rat model of partial bladder outlet obstruction.

Ecem Kaya-SezginerDidem Yilmaz-OralOmer Faruk KırlangıçSercan YilmazFatma Zeynep ÖzenMelih AşanSerap Gür

Published in: Andrology (2022)

NaBu promotes recovery of erectile function, and also significantly prevents penile fibrosis and normalizes TGF-β1 and nNOS protein expression in a rat model of PBOO. The HDAC pathway may present a promising target to prevent ED in patients with BPH.

Keyphrases

benign prostatic hyperplasia
emergency department
mouse model
spinal cord injury
lower urinary tract symptoms
transforming growth factor
liver fibrosis
histone deacetylase
nitric oxide synthase
epithelial mesenchymal transition
signaling pathway