Optimal dosing of cefotaxime and desacetylcefotaxime for critically ill paediatric patients. Can we use microsampling?
Yarmarly C Guerra ValeroTavey DorofaeffMark G CoulthardLouise SparkesJeffrey LipmanSteven C WallisJason Alexander RobertsSuzanne L ParkerPublished in: The Journal of antimicrobial chemotherapy (2022)
Dosing recommendations support the use of extended or continuous infusion to achieve cefotaxime exposure suitable for bacterial killing in critically ill paediatric patients, including those with severe or deep-seated infection. An external validation of capillary microsampling demonstrated skin-prick sampling can facilitate data-rich pharmacokinetic studies.