Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.

Joanne WongAnastasios DamdimopoulosPauliina DamdimopoulouJemma G GasperoniStephanie C TranSylvia V H GrommenBert De GroefSebastian Dworkin

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)

Together, these results suggest a defect in the epididymal extracellular matrix in Plag1-/- mice. These results imply that in addition to maintaining epididymal integrity directly, PLAG1 may also regulate several genes involved in the regulation of sperm maturation and capacitation. Moreover, PLAG1 may also be involved in regulating tissue homeostasis and ensuring proper structure and maintenance of the extracellular matrix in the epididymis.

Keyphrases

extracellular matrix
type diabetes
adipose tissue
metabolic syndrome
transcription factor
bioinformatics analysis
wild type