Login / Signup

Metal-Hydride C-C Cross-Coupling of Alkenes Through a Double Outer-Sphere Mechanism.

Nathan DaoXu-Cheng GanRyan A Shenvi
Published in: The Journal of organic chemistry (2024)
This Synopsis covers recent reports of metal-catalyzed alkene functionalizations that likely involve iterative outer-sphere reactions in which the substrate reacts directly with a metal ligand instead of with the metal center itself. Traditional metal hydride-catalyzed alkene functionalizations involve this latter pathway whereby the alkene forms part of the metal ligand sphere (i.e. an inner-sphere reaction). In contrast, alkenes do not ligate the metal in so-called outer-sphere reactions and instead react with a metal ligand. These transformations have proved crucial for the synthesis of high fraction sp 3 (F sp 3) targets, especially in hindered fragment couplings of relevance to natural product space.
Keyphrases
  • magnetic resonance
  • emergency department
  • computed tomography
  • electronic health record
  • contrast enhanced