MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization.

Yaqi ZhangXi LeShuo ZhengKe ZhangJing HeMengting LiuChengshu TuWei RaoHongyuan DuYu OuyangChangyong LiDongcheng Wu

Published in: Stem cell research & therapy (2022)

Collectively, our findings demonstrate that UC-MSCs-derived miR-146a-5p have the potential to restore renal function in DN rats through facilitating M2 macrophage polarization by targeting TRAF6. This would pave the way for the use of miRNA-modified cell therapy for kidney diseases.

Keyphrases

umbilical cord
mesenchymal stem cells
diabetic nephropathy
cell therapy
bone marrow
endothelial cells
single cell
risk assessment
human health