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BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.

Elena M PugachevaDharmendra Nath BhattSamuel Rivero-HinojosaMd TajmulLiron FedidaEmma PriceYon JiDmitri LoukinovAlexander V StrunnikovBing RenVictor V Lobanenkov
Published in: Genome biology (2024)
Thus, BORIS functions as a transcription factor that epigenetically reprograms clustered CTCF binding sites into transcriptional start sites, promoting transcription from alternative promoters in both germ cells and cancer cells.
Keyphrases
  • transcription factor
  • induced apoptosis
  • long noncoding rna
  • dna binding
  • cell cycle arrest
  • gene expression
  • genome wide identification
  • endoplasmic reticulum stress
  • oxidative stress
  • heat shock