Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals.

Robert F HillaryDaniel L McCartneyHannah M Smith Elena Bernabeu Danni A Gadd Aleksandra D ChybowskaYipeng ChengLee Murphy Nicola Wrobel Archie I Campbell Rosie M Walker Caroline Hayward Kathryn L Evans Andrew M McIntosh Riccardo E Marioni

Published in: PLoS medicine (2023)

We discovered over 100 associations between blood methylation sites and common disease states, independently of major confounding risk factors, and a need for greater standardisation among EWAS on human disease.

Keyphrases

risk factors
dna methylation
endothelial cells
gene expression
genome wide