METTL3-Mediated N6-methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis.

Yu-Cheng TsaiTsung-Han HsiehYuan-Ru Liao Ming-Tsun Tsai Tzu-Ping Lin Der-Yen Lee Jihwan ParkDonggun KimKatalin Suszták Shang-Feng Yang Chih-Ching Lin Szu-Yuan Li

Published in: Journal of the American Society of Nephrology : JASN (2024)

Our research revealed heightened METTL3-mediated m6A modification in fibrotic kidneys, particularly enriching the cGAS-STING pathway. This hypermethylation increased mRNA stability for cGAS and STING1, leading to sterile inflammation and fibrosis.

Keyphrases

oxidative stress
binding protein
single cell