Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease.

Fabienne CyprienClaudine BerrJerome J MallerChantal MeslinMélissa GentreauThibault MuraAudrey GabellePhilippe CourtetKaren RitchieMarie-Laure AncelinSylvaine Artero

Published in: Psychological medicine (2021)

High CH in late life is associated with cerebral white matter alterations, designated as early markers of dementia, and higher AD risk. Identifying lifestyle and biological determinants related to CH could provide clues on AD physiopathology and avenues for prevention strategies.

Keyphrases

white matter
multiple sclerosis
room temperature
mild cognitive impairment
cognitive decline
metabolic syndrome
subarachnoid hemorrhage
physical activity
cardiovascular disease
cognitive impairment
type diabetes
brain injury