Primary 3-Month Outcomes of a Double-Blind Randomized Prospective Study (The QUEST Study) Assessing Effectiveness and Safety of Novel High-Frequency Electric Nerve Block System for Treatment of Post-Amputation Pain.
Leonardo KapuralJim MeltonBilly KimPriyesh MehtaAbindra SigdelAlexander BautistaErika A PetersenKonstantin V SlavinJohn EidtJiang WuSaid ElshihabiJason Matthew SchwalbH Edward GarrettElias VeiziGiancarlo BarolatRavi R RajaniPeter C RheeMaged GuirguisNagy MekhailPublished in: Journal of pain research (2024)
The primary outcomes of the study were met, and the majority of Treatment patients experienced a substantial improvement in PAP (regardless of meeting the study definition of a responder). The significant in PAP was associated with significantly improved QOL metrics, and a trend towards reduced opioid utilization compared to Control. These data indicate that Altius treatment represents a significant therapeutic advancement for lower-limb amputees suffering from chronic PAP.
Keyphrases
- lower limb
- high frequency
- end stage renal disease
- chronic kidney disease
- transcranial magnetic stimulation
- clinical trial
- prognostic factors
- peritoneal dialysis
- tyrosine kinase
- spinal cord
- deep learning
- adipose tissue
- neuropathic pain
- skeletal muscle
- big data
- open label
- study protocol
- patient reported outcomes
- replacement therapy
- phase ii
- postoperative pain