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Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma.

Pei-Suen TsouPamela J PalisocNicholas A FlavahanZsuzsanna H McMahan
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our data suggest that the long-lasting effects of iloprost reflect its ability to stabilize adherens junctions, resulting in increased tubulogenesis and barrier function and reduced EndoMT. These findings provide a mechanistic basis for the use of iloprost in treating SSc patients with RP and digital ulcers.
Keyphrases
  • systemic sclerosis
  • pulmonary arterial hypertension
  • oxidative stress
  • electronic health record
  • single molecule
  • big data
  • interstitial lung disease
  • pulmonary hypertension
  • data analysis