Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma.

Pei-Suen TsouPamela J PalisocNicholas A FlavahanZsuzsanna H McMahan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Our data suggest that the long-lasting effects of iloprost reflect its ability to stabilize adherens junctions, resulting in increased tubulogenesis and barrier function and reduced EndoMT. These findings provide a mechanistic basis for the use of iloprost in treating SSc patients with RP and digital ulcers.

Keyphrases

systemic sclerosis
pulmonary arterial hypertension
oxidative stress
electronic health record
single molecule
big data
interstitial lung disease
pulmonary hypertension
data analysis