Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma.
Pei-Suen TsouPamela J PalisocNicholas A FlavahanZsuzsanna H McMahanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our data suggest that the long-lasting effects of iloprost reflect its ability to stabilize adherens junctions, resulting in increased tubulogenesis and barrier function and reduced EndoMT. These findings provide a mechanistic basis for the use of iloprost in treating SSc patients with RP and digital ulcers.