Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load.

Sanne ReijmTheresa KisselGerrie Stoeken-RijsbergenLinda M SlotCorrie M WortelHugo J van DoorenNivine E W LevarhtArieke S B KampstraVeerle F A M DerksenPleuni Ooijevaar-de HeerHolger BangJan W DrijfhoutLeendert A TrouwTom W J HuizingaTheo RispensHans U SchererRené E M Toes

Published in: Arthritis research & therapy (2021)

We provide first evidence that AMPA-IgM are cross-reactive towards different PTMs, indicating that PTM (cross-)reactivity is not confined to IgG and does not necessarily depend on extensive somatic hypermutation. Moreover, our data indicate that a diverse set of PTM antigens could be involved in the initial tolerance breach in RA and suggest that AMPA-IgM can induce complement-activation and thereby inflammation.

Keyphrases

rheumatoid arthritis
disease activity
oxidative stress
ankylosing spondylitis
dendritic cells
electronic health record
interstitial lung disease
gene expression
protein protein
machine learning
big data
systemic sclerosis
small molecule
copy number
immune response