Calibrated automated thrombogram II: removing barriers for thrombin generation measurements.
P L A GiesenA J W GulpenR van OerleH Ten CateM NagyHenri M H SpronkPublished in: Thrombosis journal (2021)
Our results showed high similarity between the results of CAT-I and CAT-II method when it is applied in control plasmas and plasmas not inhibited with a direct thrombin inhibitor. Furthermore, both the CAT-II method and ST-Genesia using the same calibration method were able to detect the effect of all oral anticoagulants. Taken together, applying a new calibration method is a significant improvement for monitoring patients on direct thrombin inhibitors while not introducing any bias to results obtained on other types of samples.