STING-mediated Syk Signaling Attenuates Tumorigenesis of Colitis‑associated Colorectal Cancer Through Enhancing Intestinal Epithelium Pyroptosis.

Wenbin GongPeizhao LiuFan ZhaoJuanhan LiuZhiwu HongHuajian RenGuosheng GuGefei WangXiuwen WuTao ZhengYun ZhaoJian-An Ren

Published in: Inflammatory bowel diseases (2021)

STING-mediated Syk signaling may regulate the tumorigenesis of CAC by modulating pyroptosis of tumor cells, and modulation of STING/Syk serves as a novel therapeutic strategy for CAC therapy.

Keyphrases

tyrosine kinase
nlrp inflammasome
stem cells
ulcerative colitis
replacement therapy