Relationship of Mitochondrial DNA Oxidation and Content with Metabolic Syndrome and Cardiovascular Risk in Obesity Phenotypes.
Mailén RojoHernán PérezAndrea Liliana MillánMaría Constanza PautassoGustavo Daniel FrechtelGloria Edith CerronePublished in: Journal of obesity (2024)
MHO presented a similar mtDNA oxidation level to NW and mtDNA content to the MUO, placing the MHO individuals as having an intermediate phenotype. Changes in mtDNA content and oxidation were correlated to the lipid profile related to obesity and/or MS presence, probably associated with oxidative stress and chronic low-grade inflammation.
Keyphrases
- mitochondrial dna
- metabolic syndrome
- copy number
- low grade
- oxidative stress
- insulin resistance
- hydrogen peroxide
- high grade
- weight loss
- type diabetes
- high fat diet induced
- uric acid
- mass spectrometry
- multiple sclerosis
- genome wide
- dna methylation
- electron transfer
- adipose tissue
- diabetic rats
- ms ms
- signaling pathway
- ischemia reperfusion injury
- induced apoptosis
- cardiovascular disease
- gene expression