Low Dose Betahistine in Combination With Selegiline Increases Cochlear Blood Flow in Guinea Pigs.

Benedikt KloosMattis BertlichJennifer L SpiegelSaskia FreytagSusanne K LauerMartin CanisBernhard G Weiss Friedrich Ihler

Published in: The Annals of otology, rhinology, and laryngology (2022)

Low dose betahistine increased cochlear microcirculation significantly when combined with selegiline. This should be investigated in further studies regarding dose-effect relation in comparison to betahistine alone. Side effects, in particular regarding circulation, should be considered carefully in view of the clinical applicability of a combination therapy in patients with MD.

Keyphrases

low dose
blood flow
combination therapy
high dose
hearing loss
atomic force microscopy
case control
single molecule