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Practical Synthesis of 1,4-Dihydropyridines on Heterogeneous Sulfonic-Modified Silica (SBA-15-SO3H) Catalyst under Mild Condition.

Tran Quang HungBan Van PhucPham Thị Thanh LoanDo Thi Lan NhiHien NguyenHoan Xuan VuDang Van DoTuan Thanh Dang
Published in: Current organic synthesis (2023)
The catalyst, SBA-15-SO3H, exhibited an efficient catalyst activity for the synthesis of 1,4-DHP derivatives in high yields from the aldehyde, β-ketoester, and NH4OAc as a nitrogen source under mild conditions and short reaction time. Bronsted acid sites of this solid catalyst were figured out to play a key role in this transformation. Interestingly, our catalyst is air-stable and can be recycled at least 5 times without losing catalytic activity.
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