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ortho -Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes.

Xuemei WeiTao CaiZhebing ZhangYanjuan LuoTianbo ShangHualiang ShenHuiting XuLe-Mao YuXiang LuoGuoqi YuRunpu Shen
Published in: The Journal of organic chemistry (2024)
A straightforward methodology for the assembly of polysubstituted naphthalenes from ortho -alkynyl benzyl alcohols, enabled by using catalytic amounts of Tf 2 O, has been developed. This transformation not only features transition-metal free and without using other bases and additives but also provides a new synthetic application for ortho -alkynyl benzyl alcohols, i.e., as C6 synthons for the construction of PAHs.
Keyphrases
  • heavy metals
  • polycyclic aromatic hydrocarbons
  • ionic liquid
  • human health
  • risk assessment
  • health risk assessment