Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice.
Limin YinJianhui ZhouTianyou LiXinghua WangWenlong XueJie ZhangLingxi LinNing WangXinyi KangYu ZhouHong LiuYang LiPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
We identified the DAT-CDK9-TFEB signaling axis as a novel regulator of lysosome biogenesis. Our study sheds light on the mechanisms of protein quality control under pathophysiological conditions.