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Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice.

Limin YinJianhui ZhouTianyou LiXinghua WangWenlong XueJie ZhangLingxi LinNing WangXinyi KangYu ZhouHong LiuYang Li
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
We identified the DAT-CDK9-TFEB signaling axis as a novel regulator of lysosome biogenesis. Our study sheds light on the mechanisms of protein quality control under pathophysiological conditions.
Keyphrases
  • quality control
  • fluorescent probe
  • living cells
  • transcription factor
  • cognitive decline
  • mouse model
  • uric acid
  • protein protein
  • sleep quality
  • small molecule
  • depressive symptoms
  • adipose tissue
  • binding protein