Subcortical Volumes as Early Predictors of Fatigue in Multiple Sclerosis.
Vinzenz FleischerDumitru CiolacGabriel Gonzalez-EscamillaMatthias GrotheSebastian StraussLara S Molina GalindoAngela RadetzAnke SalmenCarsten LukasLuisa KlotzSven G MeuthAntonios BayasFriedemann PaulHans-Peter HartungChristoph HeesenMartin StangelBrigitte WildemannFlorian Then BerghBjörn TackenbergTania KümpfelUwe K ZettlMatthias KnopHayrettin TumaniHeinz WiendlRalf GoldStefan BittnerFrauke ZippSergiu GroppaMuthuraman Muthuramannull nullPublished in: Annals of neurology (2022)
We unveiled predictive associations of specific subcortical gray matter volumes with fatigue in an early and initially untreated MS cohort. The colocalization of these subcortical structures with network hubs suggests an early role of these brain regions in terms of fatigue evolution. ANN NEUROL 2022;91:192-202.