Neuropeptide depletion in the amygdala in sudden unexpected death in epilepsy: A postmortem study.
Alyma SomaniCharlotte PerrySmriti PatodiaZuzanna MichalakMatthew EllisSanjay M SisodiyaMaria ThomPublished in: Epilepsia (2020)
A reduction in galanin in the lateral nucleus in SUDEP could represent acute depletion, relevant to postictal amygdala dysfunction. In addition, increased amygdala neuropeptides in epilepsy controls support their seizure-induced modulation, which is relatively deficient in SUDEP; this could represent a vulnerability factor for amygdala dysfunction in the postictal period.
Keyphrases
- temporal lobe epilepsy
- functional connectivity
- resting state
- prefrontal cortex
- oxidative stress
- liver failure
- drug induced
- climate change
- diabetic rats
- high glucose
- respiratory failure
- intensive care unit
- endothelial cells
- mechanical ventilation
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome