Multi-PheWAS intersection approach to identify sex differences across comorbidities in 59 140 pediatric patients with autism spectrum disorder.
Alba Gutierrez-SacristanCarlos SáezCarlos De NizNiloofar JalaliThomas N DeSainRanjay KumarJoany M ZachariasseKathe P FoxNathan PalmerIsaac KohanePaul AvillachPublished in: Journal of the American Medical Informatics Association : JAMIA (2021)
Our findings provide insights into female-enriched ASD comorbidities that are potentially important in diagnosis, as well as the identification of distinct comorbidity patterns influencing anticipatory treatment or referrals. The code is publicly available (https://github.com/hms-dbmi/sexDifferenceInASD).