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Multi-PheWAS intersection approach to identify sex differences across comorbidities in 59 140 pediatric patients with autism spectrum disorder.

Alba Gutierrez-SacristanCarlos SáezCarlos De NizNiloofar JalaliThomas N DeSainRanjay KumarJoany M ZachariasseKathe P FoxNathan PalmerIsaac KohanePaul Avillach
Published in: Journal of the American Medical Informatics Association : JAMIA (2021)
Our findings provide insights into female-enriched ASD comorbidities that are potentially important in diagnosis, as well as the identification of distinct comorbidity patterns influencing anticipatory treatment or referrals. The code is publicly available (https://github.com/hms-dbmi/sexDifferenceInASD).
Keyphrases
  • autism spectrum disorder
  • attention deficit hyperactivity disorder
  • combination therapy
  • bioinformatics analysis