New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2.
Elena V GirichAnton B RasinRoman S PopovEkaterina A YurchenkoEkaterina A ChingizovaTrinh Hoai Thi PhanNgo Thi Duy NgocMikhail V PivkinOlesya I ZhuravlevaAnton Nikolaevich YurchenkoPublished in: Marine drugs (2022)
Three new tripeptide derivatives asterripeptides A-C ( 1 - 3 ) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey's method. The isolated compounds 1 - 3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A-C were investigated.