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New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2.

Elena V GirichAnton B RasinRoman S PopovEkaterina A YurchenkoEkaterina A ChingizovaTrinh Hoai Thi PhanNgo Thi Duy NgocMikhail V PivkinOlesya I ZhuravlevaAnton Nikolaevich Yurchenko
Published in: Marine drugs (2022)
Three new tripeptide derivatives asterripeptides A-C ( 1 - 3 ) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey's method. The isolated compounds 1 - 3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A-C were investigated.
Keyphrases
  • staphylococcus aureus
  • high resolution
  • magnetic resonance
  • papillary thyroid
  • escherichia coli
  • squamous cell
  • mass spectrometry
  • biofilm formation
  • lymph node metastasis
  • candida albicans