CircPMS1 promotes proliferation of pulmonary artery smooth muscle cells, pulmonary microvascular endothelial cells, and pericytes under hypoxia.

Xiaoyi HuShang WangHui ZhaoYaqin WeiRuowang DuanRong Jiang Wen-Hui WuQinhua ZhaoSugang GongLan WangJin-Ming Liu Ping Yuan

Published in: Animal models and experimental medicine (2023)

Our results suggest that circPMS1 promotes cell proliferation through the miR-432-5p/DEPDC1 or miR-432-5p/POL2D axis in PASMCs, through the miR-433-3p/MXI1 axis in PMECs, and through the miR-3613-5p/ZFAND5 axis in PCs, which provides putative targets for the early diagnosis and treatment of PH.

Keyphrases

pulmonary artery
pulmonary hypertension
endothelial cells
coronary artery
cell proliferation
pulmonary arterial hypertension
signaling pathway
pi k akt
high glucose