The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer.
Raiane Monteiro Clacino MachadoSaber MehdizadehHadi Esmaeili Gouvarchin GhalehMorteza IzadiBahman Jalali KondoriRuhollah DorostkarSeyed Morteza HosseiniPublished in: Current cancer drug targets (2024)
The results of the current study suggest that MSCs loaded with oncolytic CVA21 therapy for the CRC mouse model may have some potential advantages. On the other hand, the results of the study showed that, in addition to activating the acquired immune system, the use of MSCs loaded with oncolytic CVA21 also stimulates the innate immune system by increasing levels of nitric oxide.