Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients.

Ahmed K Farag Lennart Matthias RoesnerSusanne WieschowskiAnnice HeratizadehBritta Eiz-VesperWilliam Wai-Hung Kwok Rudolph ValentaThomas Werfel

Published in: Allergy (2021)

We demonstrate that FBP1 contains immunodominant peptides that induce a specific pro-inflammatory T helper cell response with increased Th2 levels that can drive an allergic inflammation in sensitized AD patients.

Keyphrases

end stage renal disease
staphylococcus aureus
inflammatory response
ejection fraction
newly diagnosed
binding protein
peritoneal dialysis
oxidative stress
single cell
dendritic cells
cell therapy
bone marrow
toll like receptor
patient reported
lipopolysaccharide induced
candida albicans
lps induced