Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort Study.
Kabir O OlaniranAndrew S AllegrettiSophia H ZhaoMaureen M AchebeNwamaka D EneanyaRavi I ThadhaniSagar U NigwekarSahir KalimPublished in: Journal of the American Society of Nephrology : JASN (2019)
Sickle cell trait and disease are associated with faster eGFR decline in black patients, with faster decline in sickle cell disease. Low hemoglobin S was associated with faster eGFR decline in sickle cell trait but may be confounded by concurrent hemoglobinopathies. Prospective and mechanistic studies are needed to develop best practices to attenuate eGFR decline in such patients.