Improved spatial resolution of infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging using a reflective objective.
Alena N JoignantHongxia BaiJeffrey G ManniDavid C MuddimanPublished in: Rapid communications in mass spectrometry : RCM (2022)
A Schwarzschild-like reflective objective was successfully incorporated into the NextGen source and characterized on mammalian tissue using an ice matrix. The corresponding improvement in spatial resolution facilitates the future expansion of IR-MALDESI applications to include those that require fine structural detail.