Tumor infiltrating CD103+ tissue residentmemory T cells and CD103-CD8+ T cells in HNSCC are linked to outcome in primary but not metastatic disease.
Adrian von WitzlebenMatthew J EllisGareth J ThomasThomas K HoffmannRichard J JacksonSimon LabanChristian Hermann OttensmeierPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
We confirm the prognostic impact of TIL in primary tumors and in recurrences. TRM cell density in lymph node metastases was not linked to outcome. The role of TIM3, as a therapeutic target remains to be defined.