Indolocarbazole alkaloid Loonamycin A inhibits triple-negative breast cancer cell stemness and Notch signalling.

Wenwen XueWuhao LiYing YuBo ZhangYixue WangLin ZhouZhixiu ChenLiwei WangHuiming GeQiang XuYan Shen

Published in: The Journal of pharmacy and pharmacology (2023)

These results reveal a novel bioactivity of indolocarbazole-type alkaloids and provide a promising Notch-inhibiting small molecular candidate for triple-negative breast cancer therapy.

Keyphrases

cancer therapy
cell proliferation
stem cells
drug delivery
signaling pathway
epithelial mesenchymal transition
genome wide
single cell
single molecule