Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis.
Eiichi TokudaItsuki AnzaiTakao NomuraKeisuke ToichiMasahiko WatanabeShinji OharaSeiji WatanabeKoji YamanakaYuta MorisakiHidemi MisawaYoshiaki FurukawaPublished in: Molecular neurodegeneration (2017)
Our findings here suggest that the SOD1 oligomerization through the disulfide-crosslinking associates with exposure of the SOD1 structural interior and is a pathological process occurring in the SOD1-ALS cases.