CD24hiCD27+Bregs within metastatic lymph nodes promote multi-drug resistance in breast cancer.

Huanhuan Huang Yao Yao Lesang Shen Jingxin Jiang Ting Zhang Jia Xiong Jiaxin Li Shanshan Sun Siwei Zheng Fang Jia Jun Zhou Xiuyan Yu Wuzhen Chen Jun Shen Wenjie Xia Xuan Shao Qingqing Wang Jian Huang Chao Ni

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our study reveals the pivotal role of CD24hiCD27+ Bregs in promoting drug resistance by interacting with BC cells in mLNs, providing novel evidence for an improved strategy of chemo-immunotherapy combination for BC patients with mLNs.

Keyphrases

lymph node
induced apoptosis
squamous cell carcinoma
small cell lung cancer
cell cycle arrest
photodynamic therapy
signaling pathway
cancer therapy
oxidative stress
early stage
young adults
breast cancer risk