Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6/Tripartite Motif Containing 28/Zinc Finger Protein 354C Corepressor Complex.

Zhe LiXinyuan LuYanfang LiuJingjing ZhaoShengzhe MaHaoxiang YinShenglin HuangYingjun Zhao Xiang-Huo He

Published in: Hepatology (Baltimore, Md.) (2021)

Our findings suggest that LINC00624 acts as a molecular decoy that sequesters the HDAC6-TRIM28-ZNF354C transcriptional corepressor complex away from the specific genomic loci, and that it can potentially be a therapeutic target in HCC.

Keyphrases

histone deacetylase
long non coding rna
long noncoding rna
cell proliferation
genome wide
gene expression
transcription factor
copy number
protein protein
single molecule
genome wide association study
heat shock protein