An Ex Vivo Organotypic Culture Platform for Functional Interrogation of Human Appendiceal Cancer Reveals a Prominent and Heterogenous Immunological Landscape.
Jonathan R WeitzTatiana Hurtado de MendozaHervé TiriacHyojae James LeeSiming SunBharti GargJay PatelKevin LiJoel M BaumgartnerKaitlin J KellyJula VeerapongMojgan HosseiniYuan ChenAndrew M LowyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
This study demonstrates an approach to study appendiceal cancer therapeutics and pathobiology in a preclinical setting. These methods may be broadly applicable to the study of other malignancies.