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Bottom-up PBPK modeling of phenytoin brain disposition in postpartum newborns after intrauterine dosing.

Mo'tasem M Alsmadi
Published in: Drug metabolism and personalized therapy (2024)
The salivary TDM of phenytoin can be a more convenient option for avoiding phenytoin brain toxicity in newborns of epileptic mothers. Still, the appropriateness of using the same adult values of phenytoin anticonvulsant and toxic effects for infants needs investigation.
Keyphrases
  • oxidative stress
  • pregnant women
  • white matter
  • resting state
  • gestational age
  • low birth weight
  • cord blood
  • cerebral ischemia
  • multiple sclerosis
  • preterm infants
  • preterm birth
  • blood brain barrier