Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response.
Adrian M ShieldsSian E FaustiniMarisol Perez-ToledoSian JossiJoel D AllenSaly Al-TaeiClaire BackhouseLynsey DunbarDaniel EbanksBeena EmmanuelAduragbemi A FaniyiMark I GarveyAnnabel GrinbergsGolaleh McGinnellJoanne O'NeillYasunori WatanabeMax CrispinDavid C WraithAdam F CunninghamMark T DraysonAlex G RichterPublished in: medRxiv : the preprint server for health sciences (2020)
Assays employing combined antibody detection demonstrate enhanced seroepidemiological sensitivity and can detect prior viral exposure even when PCR swabs have been negative. We demonstrate an association between known ethnodemographic risk factors associated with mortality from COVID-19 and the magnitude of serological responses in mild-to-moderate disease. The combination of cough, and/or fever and/or anosmia identifies the majority of individuals who should self-isolate for COVID-19.