The selective serotonin reuptake inhibitors, sertraline and paroxetine, improve islet beta-cell mass and function in vitro.
Toczyska KlaudiaNaila HaqZekun LyuGavin A BewickZhao MinHannah RosaStarikova JessicaLiu BoShanta Jean PersaudPublished in: Diabetes, obesity & metabolism (2024)
Our data demonstrate that sertraline and paroxetine act directly on beta cells to enhance glucose-stimulated insulin secretion and stimulate beta-cell mass expansion by increasing proliferation and decreasing apoptosis. These drugs are therefore likely to be appropriate for treating depression in people with type 2 diabetes.
Keyphrases
- cell cycle arrest
- single cell
- induced apoptosis
- cell therapy
- cell death
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- depressive symptoms
- electronic health record
- type diabetes
- blood pressure
- metabolic syndrome
- big data
- blood glucose
- adipose tissue
- pi k akt
- deep learning
- skeletal muscle
- insulin resistance
- glycemic control