Stem cell-derived exosomes from human exfoliated deciduous teeth promote angiogenesis in hyperglycemic-induced human umbilical vein endothelial cells.
Thanapat SunartvanichkulTawepong ArayapisitSujiwan Seubbuk SangkhamaneeChaiyapol ChaweewannakornKengo IwasakiPhatchanat KlaihmonHathaitip SritanaudomchaiPublished in: Journal of applied oral science : revista FOB (2023)
Our data suggest that the use of SHED-derived exosomes potentially increases angiogenesis in HUVEC under hyperglycemic conditions, which includes increased cell proliferation, migration, tubular structures formation, GATA2 gene, and CD31 protein expression. SHED-exosome usage may provide a new treatment strategy for periodontal patients with diabetes mellitus.
Keyphrases
- endothelial cells
- high glucose
- stem cells
- cell proliferation
- mesenchymal stem cells
- vascular endothelial growth factor
- transcription factor
- high resolution
- genome wide
- copy number
- electronic health record
- big data
- cell therapy
- oxidative stress
- combination therapy
- mass spectrometry
- bone marrow
- deep learning
- adipose tissue
- data analysis