The relationship between TNF-α gene promoter polymorphism (- 1211 T > C), the plasma concentration of TNF-α, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer.
Radosław MlakTomasz PowrózekAnna BrzozowskaIwona Homa-MlakMarcin MazurekPaweł GołębiowskiGrzegorz SobieszekTeresa Małecka-MassalskaPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2019)
High TNF-α plasma concentration and CC genotype of TNF-α are related to the higher risk of more severe OM in patients irradiated due to HNC. High TNF-α plasma concentration and CC genotype of TNF-α are independent prognostic factors for patients subjected to RTH due to HNC.