Dual effects of S-adenosyl-methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP.
Rebeca Araujo CantelmoNeife Aparecida G Dos SantosAntonio Cardozo Dos SantosSâmia Regiane Lourenço JocaPublished in: The Journal of pharmacy and pharmacology (2020)
(1) SAM might induce neurotoxic or neuroprotective effects on PC12 cells, depending on the exposure conditions; (2) DNMT inhibitors might attenuate the MPP+ exacerbation toxicity induced by SAM; (3) DNA methylation might be involved in the observed effects of SAM (needs further investigation).