Novel genetic loci in early-onset gout derived from whole genome sequencing of an adolescent gout cohort.
Aichang JiYang SuiXiaomei XueXiaopeng JiWenrui ShiYongyong ShiRobert TerkeltaubNicola DalbethRiku TakeiZhen LiuMingshu SunMaichao LiJie LuLingling CuiZhen LiuCan WangXinde LiLin HanZhanjie FangWenyan SunYue LiangYuwei HeGuangmin ZhengXuefeng WangJiayi WangHui ZhangLei PangHan QiYushuang LiZan ChengZhiqiang LiJingfa XiaoChangqing ZengTony Raymond MerrimanHongzhu QuXiangdong FangChanggui LiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
This is the first comprehensive genetic characterization of adolescent-onset gout. The identified risk loci of early-onset gout mediate inflammatory responsiveness to crystals that could mediate gouty arthritis. This study will contribute to risk prediction and therapeutic interventions to prevent adolescent-onset gout.