Transcriptome profiling of the diaphragm in a controlled mechanical ventilation model reveals key genes involved in ventilator-induced diaphragmatic dysfunction.
Ruining LiuGang LiHaoli MaXianlong ZhouPengcheng WangYan ZhaoPublished in: BMC genomics (2021)
This study provides a novel perspective on the molecular mechanism of DE lncRNAs and mRNAs in a CMV model, and indicates that the inflammatory signaling pathway and lipid metabolism may play important roles in the pathophysiological mechanism and progression of VIDD.
Keyphrases
- mechanical ventilation
- acute respiratory distress syndrome
- intensive care unit
- signaling pathway
- respiratory failure
- oxidative stress
- single cell
- extracorporeal membrane oxygenation
- high glucose
- diabetic rats
- pi k akt
- epithelial mesenchymal transition
- genome wide
- induced apoptosis
- cell proliferation
- transcription factor
- endoplasmic reticulum stress