A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.

Peiran YangCai ReadRhoda E KucDuuamene NyimanuThomas L WilliamsAlexi CrosbyGuido BuonincontriMark SouthwoodStephen J SawiakRobert C GlenNicholas W MorrellAnthony P DavenportJanet J Maguire

Published in: British journal of pharmacology (2019)

Our findings suggest that chronic treatment with MM07 is beneficial in this animal model of pulmonary arterial hypertension by addressing disease aetiology. These data support the development of G protein-biased apelin receptor agonists with improved pharmacokinetic profiles for use in human disease.

Keyphrases

pulmonary arterial hypertension
pulmonary artery
pulmonary hypertension
endothelial cells
oxidative stress
electronic health record
big data
coronary artery
artificial intelligence
replacement therapy
drug induced