Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice.

Mari HoyaTakeshi NagamatsuTatsuya FujiiDanny J SchustHiroko OdaNaoya AkibaTakayuki IriyamaKei KawanaYutaka OsugaTomoyuki Fujii

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

The resistance of mouse pregnancy to iNKT cell stimulation by OCH and the prevention of AGC-induced fetal loss by IL-4 were demonstrated. In pregnancy, the regulation of Th1/Th2 polarity by iNKT cells is a key to healthy fetal growth.

Keyphrases

induced apoptosis
preterm birth
cell cycle arrest
pregnancy outcomes
cell death
single cell
oxidative stress
type diabetes
signaling pathway
cell therapy
high glucose
metabolic syndrome
insulin resistance
high fat diet induced