Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy.

Lihua ZhangZhen Zou Yanli Lei Zhihe QingYu ZengHaiyan SunFeng Feng Ronghua Yang

Published in: Chemical communications (Cambridge, England) (2021)

A clamp-like triplex switch (CTS) able to simultaneously downregulate an overexpressed onco-miRNA and replenish the lost tumor-suppressive miRNA in a controllable manner was developed for enhanced gene therapy. Compared to the "unidirectional" regulation approach, the CTS displayed improved anti-tumor efficacy in vitro and was harmless to healthy cells.

Keyphrases

gene therapy
induced apoptosis
cell cycle arrest
cell death
oxidative stress