Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function.

Agnieszka ZmyslowskaMiljan KuljaninBeata MalachowskaMarcin StanczakDominika MichalekAneta WlodarczykDagmara GrotJoanna TahaBartłomiej PawlikMagdalena Lebiedzińska-ArciszewskaHanna NieznanskaMariusz R WieckowskiPiotr RieskeJoseph D ManciasMaciej BorowiecWojciech MlynarskiWojciech Fendler

Published in: Cell communication and signaling : CCS (2021)

Our results show the functional and morphological secondary mitochondrial damage in patients with WFS. Video Abstract.

Keyphrases

oxidative stress
endothelial cells
single cell
cell therapy
induced pluripotent stem cells