Evaluating RB1 and p53 as diagnostic markers in treatment-related neuroendocrine prostate cancer through immunohistochemistry and genomic analysis of RB1 and TP53.
Hideto UekiNaoe JimboTomoaki TerakawaTakuto HaraTaisuke TobeJunichiro HirataNaoto WakitaYasuyoshi OkamuraKotaro SuzukiYukari BandoKoji ChibaJun TeishimaYuzo NakanoHideaki MiyakePublished in: The Prostate (2024)
This study indicated high concordance between IHC and NGS findings for RB1/RB1 and p53/TP53 in t-NEPC. We provide a comprehensive benchmark of NGS performance compared with IHC, and these findings may help increase the diagnostic sensitivity of t-NEPC.