ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway.

Chengcheng SunMeixia LiuJiangang LiuTingting ZhangLei ZhangHao LiZenggang Luo

Published in: Neuropsychiatric disease and treatment (2021)

SMYZD may provide a potential therapeutic strategy via activating the AMPK/PPARα/PGC-1α/UCP2 signal pathway to improve mitochondrial structure and energy metabolism thereby alleviate vascular cognitive impairment.

Keyphrases

cognitive impairment
signaling pathway
skeletal muscle
oxidative stress
insulin resistance
pi k akt
epithelial mesenchymal transition
protein kinase
white matter
resting state
functional connectivity
brain injury