Mood Symptoms and Chronic Fatigue Syndrome Due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron.
Abbas F AlmullaAl-Karrar Kais Abdul JaleelAli Abbas Abo AlgonChavit TunvirachaisakulHayder K HassounHussein Kadhem Al-HakeimMichael MaesPublished in: Brain sciences (2023)
Around 50% of remitted RRMS patients show activation of immune-inflammatory pathways in association with mood and chronic-fatigue-like symptoms. IRS and CIRS activation as well as the aberrations in the erythron are new drug targets to treat chronic fatigue and affective symptoms due to MS.
Keyphrases
- multiple sclerosis
- sleep quality
- bipolar disorder
- depressive symptoms
- end stage renal disease
- white matter
- newly diagnosed
- ejection fraction
- physical activity
- chronic kidney disease
- copy number
- peritoneal dialysis
- ms ms
- emergency department
- rheumatoid arthritis
- prognostic factors
- patient reported outcomes
- dna methylation
- gene expression
- adverse drug
- anorexia nervosa