New Insights into the Molecular Profile of Penile Squamous Cell Carcinoma.
Bradley Alexander McGregorGuru P SonpavdePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Genomic alterations in penile squamous cell carcinoma (PSCC) appear similar to squamous cell carcinomas of the head and neck and esophagus but not lung, skin, bladder, and cervix. PSCCs display genomic heterogeneity, low mutation burden, and potentially actionable alterations in the Notch, DNA repair, kinase, and cell-cycle pathways.See related article by Chahoud et al., p. 2560.
Keyphrases
- cell cycle
- dna repair
- squamous cell carcinoma
- squamous cell
- cell proliferation
- dna damage
- copy number
- dna damage response
- lymph node metastasis
- locally advanced
- single cell
- spinal cord injury
- high grade
- soft tissue
- radical prostatectomy
- protein kinase
- preterm birth
- tyrosine kinase
- risk factors
- radiation therapy
- oxidative stress
- wound healing
- dna methylation
- urinary tract
- drug induced
- genome wide